Use of 3-hydroxypropinoaldehyde in crosslinking and sterilizing a biomolecule, and a biocompatible implant, substitute or wound dressing containing the crosslinked biomolecule

摘要

A use of 3-hydroxypropinoaldehyde in the manufacture of a biocompatible implant, substitute or wound dressing is disclosed, which involves crosslinking an amine-containing biomolecule including chitosan, hemoglobin and a connective-tissue protein such as collagen or gelatin derived from a collagenous source with 3-hydroxypropinoaldehyde.