| 摘要 |
PCT No. PCT/GB97/00176 Sec. 371 Date Oct. 13, 1998 Sec. 102(e) Date Oct. 13, 1998 PCT Filed Jan. 21, 1997 PCT Pub. No. WO97/27312 PCT Pub. Date Jul. 31, 1997The invention provides a process for the preparation of aspartic acid via a fermentation process for the preparation of ammonium fumarate, wherein the pH of the fermentation broth is controlled by the addition of a calcium base to produce a calcium fumarate precipitate, characterized in that ammonium fumarate is produced by separating the precipitated calcium fumarate from the fermentation broth, and reacting the same with a reagent selected from ammonia, ammonium carbonate, ammonia in combination with CO2 and mixtures thereof, to form ammonium fumarate and a co-product selected from calcium carbonate and calcium hydroxide, wherein the energy of indirect neutralization of fumaric acid by ammonia serves as the driving force for the conversion of calcium fumarate to the desired ammonium fumarate product and for the regeneration of a calcium base reagent, and wherein diammonium fumarate is enzymatically converted to ammonium aspartate and acidulated to from aspartic acid. |
