发明名称 |
5-CHLORO-6-PHENYL-2-(4-TRIFLUOROMETHYLPHENYL)-4-PYRIMIDINYLAMINO ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATE OF THESE COMPOUNDS |
摘要 |
<p>A Ä5-chloro-6-phenyl-2-(4-trifluoromethylphenyl)-4-pyrimidinylaminoÜacet amide derivative of the formula (I): <CHEM> wherein R<1> is a methyl group or a cyclopropyl group, and a pharmaceutical composition containing the same. Said compounds exhibit a potent anti-rheumatoid activity and show low toxicity, and hence, they are useful as an agent for prophylaxis or treatment of immuno inflammatory diseases such as rheumatoid diseases (e.g., rheumatoid arthritis, Behçet disease, ankylosing spondylitis, etc.) and autoimmune diseases (e.g., multiple sclerosis, systemic lupus erythematosus, Sj¦gren syndrome, etc.).</p> |
申请公布号 |
EP1236721(A1) |
申请公布日期 |
2002.09.04 |
申请号 |
EP20000974834 |
申请日期 |
2000.11.09 |
申请人 |
DAINIPPON PHARMACEUTICAL CO., LTD. |
发明人 |
MURATA, TERUYA;OHNO, KAZUNORI;TANAKA, MASAYASU;ITOH, MARI |
分类号 |
A61P29/00;A61P37/06;C07D239/42;(IPC1-7):C07D239/42;A61K31/505 |
主分类号 |
A61P29/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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