发明名称 |
PROCESS FOR THE PREPARATION OF 2-HALOMETHYL-PENEMS AND THEIR USE FOR THE PREPARATION OF ANTIBACTERIAL PENEMS |
摘要 |
<p>Process for the preparation of 2-halomethyl-penems (I) comprising (a) reacting an acetoxy-(protected hydroxyethyl)-2-azetidinone (III) with a 2-halothioacetic acid to form a 3-haloacetylthioazetidinone (V), (b) reacting (V) with oxalyl chloride to give an intermediate (VII), acylated on the beta-lactamic nitrogen, and (c) cyclizing (VII) in the presence of an organic phosphate or phosphonite to produce the corresponding 2-halomethyl-penem (I).</p> |
申请公布号 |
EP0883620(B1) |
申请公布日期 |
2002.09.04 |
申请号 |
EP19970903325 |
申请日期 |
1997.02.19 |
申请人 |
A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L.;ISTITUTO LUSO FARMACO D'ITALIA S.P.A. |
发明人 |
PERROTTA, ENZO;ALTAMURA, MARIA |
分类号 |
C07D499/883;C07D205/09;C07D499/88;C07D499/887;(IPC1-7):C07D499/88 |
主分类号 |
C07D499/883 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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