发明名称 |
GENES AND PROTEINS INVOLVED IN THE BIOSYNTHESIS OF ENEDIYNE RING STRUCTURES |
摘要 |
-103- Five protein families cooperate to form the warhead structure that characterizes enediyne compounds, both chromoprotein enediynes and non-chromoprotein enediynes. The protein families include a polyketide synthase and thioestera se protein which form a polyketide synthase catalytic complex involved in warhead formation in enediynes. Genes encoding a member of each of the five protein families are found in all enediyne biosynthetic loci. The genes and proteins may be used in geneti c engineering applications to design new enediyne compounds and in methods to identify new enediyne biosynthetic loci. |
申请公布号 |
CA2445687(A1) |
申请公布日期 |
2002.09.04 |
申请号 |
CA20022445687 |
申请日期 |
2002.05.21 |
申请人 |
ECOPIA BIOSCIENCES INC. |
发明人 |
FARNET, CHRIS M.;STAFFA, ALFREDO;ZAZOPOULOS, EMMANUEL |
分类号 |
C07K14/195;C12N9/00;C12N9/10;C12N9/16;C12N15/31;C12N15/52;C12N15/54;C12N15/55;C12N15/63;C12P13/00;C12P17/02;C12P19/44;C12P19/60;C12P21/00;C12P21/02;C12Q1/68;G01N33/50;G06F19/00 |
主分类号 |
C07K14/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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