发明名称 |
Methods of using inhibitors of cyclophilin rotamase activity to affect neurological activity |
摘要 |
This invention relates to the method of using neurotrophic cyclophilin inhibitor compounds having an affinity for cyclophilin-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
|
申请公布号 |
US6444643(B1) |
申请公布日期 |
2002.09.03 |
申请号 |
US19990321762 |
申请日期 |
1999.05.28 |
申请人 |
GUILFORD PHARMACEUTICALS INC.;JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
STEINER JOSEPH P.;HAMILTON GREGORY S.;SNYDER SOLOMON H. |
分类号 |
A61K38/00;A61K38/13;A61P25/00;A61P25/16;A61P25/28;C07K7/64;C12N5/0793;(IPC1-7):A61K38/03 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|