发明名称 |
Use of GPR30 receptor ligands to mediate neurotrophic action |
摘要 |
Neurological dysfunction is prevented or treated by the administration of ligands that activate the GPR30 receptor. Ligands include estrogens and structurally related molecules. Preferably the GPR30 ligand is an orally available drug that can cross into the brain from blood. Screening methods are provided for ligands that do not activate other estrogen receptors, and therefore do not have the classical estrogenic effects attributable to these receptors.
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申请公布号 |
US6444420(B2) |
申请公布日期 |
2002.09.03 |
申请号 |
US20010844402 |
申请日期 |
2001.04.26 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
MOBLEY WILLIAM C.;WEIGEL RONALD J.;WU CHENGBIAO;LAM HAR HIU DAWN |
分类号 |
A61K31/00;A61K31/565;A61K38/17;G01N33/68;G01N33/74;(IPC1-7):C12Q1/00 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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