| 摘要 |
A new embolic agent, bioabsorbable polymeric material (BPM) is incorporated to a Guglielmi detachable coil (GDC) to improve long-term anatomic results in teh endovascular treatment of intracranial aneurysma. The embolic agent, comprised at least in part of at least one biocompatible and bioabsorbable polmer and growth factors, is carried by hybrid bioactive coils and is used to accelerate histopathologic transformation of unroganized clot into fibrous connective tissue in experimental aneurysms. An endovascular cellular manipulation and inflammatory response are elicited from implantation in a vascular compartment or any intrluminal location. Thrombogenicity ofthe biocompatible and bioabsorbable polmer is controlled bz the composition of the polymer. The coil further is comprised at least in part of a growth factor or more particularly a vascular endothelial growth factor, a basic fibroblast growth factor or other growth factors. The biocompatible and bioabsorbable polmer is in the illustrated embodiment at least one polymer selected for the group consisting of polyglycolic acid, poly-glycolic acid/poly-L-lactic acid copolymers, polcaprolactive, polyhydroxbutyrate/hydroxyvalerate copolmers, poly-L-lactide. Poldioxanone polycarbonates, and polyanhydrides. |
