EPOTHILONE DERIVATIVES FOR THE TREATMENT OF REFRACTORY TUMORS

摘要

A method of treating tumors in a mammal, especially a human that have demonstrated resistance to oncology with taxane oncology agents is disclosed . The method is effective where the tumor has initially been unresponsive to taxane therapy or has developed resistance during the course of treatment. T he method comprising the administration of an epothilone derivative selected fr om those represented by formula I:[chemical drawing]The subject epothilone derivatives are advantageous in addition to their enhanced potency and effectiveness against tumors that have demonstrated resistance to therapy wi th taxane oncology agents in that both[chemical drawing]The subject epothilone derivatives are advantageous in addition to their enhanced potency and effectiveness against tumors that have demonstrated resistance to therapy wi th taxane oncology agents in that both are efficacious upon oral administration .