| 摘要 |
1. A method for treating or inhibiting oral squamous cell carcinoma in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of the formula or a pharmaceutically acceptable salt thereof of an addition base, wherein R1 is C1-C5 alkyl, C1-C4 alkenyl, (C1-C4 alkyl)thio, halo, or R2 substituted phenyl; each R2 and R1 are each independently hydrogen, halo, hydroxy, C1-C4 alkyl, C1-C4 alkoxy; Y and X are -O- or -CH2-; Z is CH2-CH2 or CH2CH2CH2CH2; A is -O-, -CH2-, CH(R7-substituted phenyl)- or -C(CH3)2-; R4 is each R7 is hydrogen, C1-C4-alkyl, R8 is hydrogen or halogen; and with the proviso that when X is -O-, Y is not O. 2. The method as claimed in Claim 1, wherein a compound is 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic acid or a pharmaceutically acceptable salt or solvate thereof. 3. The method as claimed in Claim 1, wherein a compound is 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-carboxy-phenoxy)phenyl)propionic acid or a pharmaceutically acceptable salt or solvate thereof. 4. The method as claimed in Claim 1, wherein a compound is 1-(4-(carboxy-methoxy)phenyl)-1-(1H-tetrazol-5-yl)-6-(2-ethyl4- (4-fluorophenyl) -5-hydroxyphenoxy)hexane or a pharmaceutically acceptable salt or solvate thereof. 5. The method as claimed in Claim 1, wherein a compound is 3-[4-[7-carboxy-9-oxo-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxyi -propoxy] -9H-xanthene] ] propanoic acid or a pharmaceutically acceptable salt or solvate thereof. 6. The method as claimed in Claim 1, wherein a compound is 5- [3-[2-(1-carboxy)-ethyl]-4-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy] -propoxy] phenyl] -4-pentynoic acid or a pharmaceutically acceptable salt or solvate thereof. 7. The method as claimed in Claims 1 to 6 in which the mammal is a human. |
