TRYPTASE INHIBITORS TRYPTASE INHIBITORS

摘要

Tryptase inhibitors of the formula (I) in which M is a central building bloc k containing two acetylene groups; A1 and A2 are carbonyl containing linking groups; K1 is B3-X1, -B3-Y1 or B3-Z1-B5-X1; K2 is B4-X2, -B4-Y2 or B4-Z2-B6- X2, B3 and B4 are identical or different and are a bond or 1-4C-alkylene; B5 and B6 are identical or different and are a bond of 1-2C-alkylene; X1 and X2 are identical or different and are amino, aminocarbonyl or amidino; Y1 and Y 2 are imidazol-1-yl; Z1 and Z2 are identical or different and are 5,2- pyridinylene, 6-methyl-5,2-pyridinylene, 4,1-piperidinylene, 3,6-indazolylen e, 3,6-indolylene, 1,3-phenylene, 1,4-phenylene, 1,3-cyclohexylene or 1,4- cyclohexylene.