发明名称 TRANSMURAL CONCENTRIC MULTILAYER INGROWTH MATRIX WITHIN WELL-DEFINED POROSITY
摘要 A multilayer ingrowth matrix is constructed within well-defined porosity of a prosthetic material. The matrix consists of either proteinaceous or synthetic layers or gradients, or a combination of proteinaceous and synthetic layers or gradients. Each layer within the matrix is designed to achieve a specific function, such as facilitation of ingrowth of a particular cell type or release of a particular growth factor. The well-defined porosity is in the form of either helically oriented, interconnected transmural ingrowth channels, or a porous wall structure containing uniformly shaped pores (i.e. voids) in a very narrow size range, or a combination of channels and pores. This invention allows for uninterrupted ingrowth of connective tissue into walls of a synthetic graft prosthesis made from the prosthetic material. Furthermore, this invention can produce small diameter prostheses having an internal diameter of 6 mm or less.
申请公布号 WO0234307(A3) 申请公布日期 2002.08.29
申请号 WO1999US27567 申请日期 1999.11.19
申请人 MEDTRONIC, INC. 发明人 ZILLA, PETER, PAUL;BEZUIDENHOUT, DEON;DOWER, THERESA, YVONNE
分类号 A61L27/22;A61L27/56;A61L31/04;A61L31/14 主分类号 A61L27/22
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