摘要 |
PCT No. PCT/GB97/03130 Sec. 371 Date Jun. 18, 1999 Sec. 102(e) Date Jun. 18, 1999 PCT Filed Nov. 13, 1997 PCT Pub. No. WO98/28283 PCT Pub. Date Jul. 2, 1998A process for making a 1,2-benzisothiazolin-3-one by cycling a bisamide precursor under alkaline conditions in the presence of oxygen or an oxygen-release compound in the presence of a nitrogen, sulphur or phosphorus nucelophile. Preferred nucelophiles are ammonia, primary, secondary and tertiary amines, amides, pyridines and quinolines |