NOVEL SUBSTITUTION MUTANT RECEPTORS AND THEIR USE IN A NUCLEAR RECEPTOR-BASED INDUCIBLE GENE EXPRESSION SYSTEM

摘要

This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system a nd methods of modulating the expression of a gene in a host cell for applicatio ns such as gene therapy, large scale production of proteins and antibodies, cel l- based high throughput screening assays, functional genomics and regulation o f traits in transgenic organisms.