发明名称 |
ANTI-INFLAMMATORY PEPTIDES DERIVED FROM C-REACTIVE PROTEIN |
摘要 |
A peptide corresponding to positions 89-96 of the human C-reactive protein (CRP) of the formula: Val89-Thr-Val-Ala-Pro-Val-His-Ile96 and modifications thereof obtained by substitution, elongation, amidation of the C-terminal or acylation of the N-terminal, inhibit in vitro the enzymatic activity of human leukocyte elastase (hLE) and/or of human leukocyte cathepsin G(hCG) and can be used for the treatment of chronic inflammation conditions such as rheumatoid arthritis, pulmonary emphysema and cystic fibrosis.
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申请公布号 |
US2002119917(A1) |
申请公布日期 |
2002.08.29 |
申请号 |
US19990117380 |
申请日期 |
1999.01.27 |
申请人 |
FRIDKIN MATITYAHU;YAVIN ERAN J. |
发明人 |
FRIDKIN MATITYAHU;YAVIN ERAN J. |
分类号 |
A61K38/00;C07K14/47;(IPC1-7):A61K38/00 |
主分类号 |
A61K38/00 |
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地址 |
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