The present invention provides for novel immungens that are comprised of an activated polyhydroxypolymer backbone to which is attached 2 separate antigenic determinants. The 1st antigenic determinant includes a B-cell or CTL epitope and the 2nd antigenic determinant includes a T-helper epitope. In preferred embodiments, the antigenic determinants are derived from different molecules and species. Exemplary immunogens of the invention are constituted of a linear tresyl-activated dextran backbone to which is coupled B-cell or CTL epitopes of an antigen and to which is also coupled universal T-helper epitopes. Also disclosed are immunogenic compositions comprising the immunogens, methods of immunisation and a mehtod for identification of suitable immunogens of the invention.
申请公布号
WO02066056(A2)
申请公布日期
2002.08.29
申请号
WO2002DK00112
申请日期
2002.02.19
申请人
PHARMEXA A/S;NIELSEN, KLAUS, GREGORIUS;KOEFOED, PETER