| 摘要 |
<p>The present invention relates generally to a method of identifying differences between nucleic acid molecules and provides a method capable of identifying a variation in a nucleotide sequence in nucleic acid molecules based on the selectivity of oxidizing agents towards mismatched or unmatched bases in a nucleic acid duplex. The method of the present invention enables the detection of nucleotide variations, such as resulting from base changes (mutations and polymorphisms) in target nucleic acid heteroduplex molecules derived from wildtype and mutant homoduplexes</p> |
