| 发明名称 |
4-Benzodioxolyl substituted pyrrolidine-3-carboxylic acid derivatives useful as endothelin antagonists |
| 摘要 |
[2S,3R,4S]-2-(2,2-Dimethylpentyl)-4-(7-methoxy-1,3-benzodioxol-5-yl)-1 -(N,N-di-(n-butyl)-aminocarbonylmethyl)-pyrrolidine-3-carboxylic acid and [2S,3R,4S]-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-[(N-butyl-N- (4-dimethylaminobutyl)-amino)carbonylmethyl]-pyrrolidine-3-carboxylic acid, a pharmaceutically acceptable salt thereof and the pharmaceutical composition thereof are useful for antagonizing the endothelin activity. |
| 申请公布号 |
NZ502395(A) |
申请公布日期 |
2002.08.28 |
| 申请号 |
NZ19980502395 |
申请日期 |
1998.07.27 |
| 申请人 |
ABBOTT LABORATORIES |
发明人 |
KING, STEVEN A;WITTENBERGER, STEVEN J;WINN, MARTIN;BOYD, STEVEN A;HUTCHINS, CHARLES W;JAE, HWAN-SOO;TASKER, ANDREW S;VON GELDERN, THOMAS W;KESTER, JEFFREY A;SORENSEN, BRYAN K;SZCZEPANKIEWICZ, BRUCE G;HENRY, KENNETH J;LIU, GANG |
| 分类号 |
C07D491/048;A61K31/40;A61K31/41;A61K31/423;A61K31/435;A61K31/4355;A61K31/495;A61K31/506;A61K31/535;A61K31/55;A61P1/00;A61P1/04;A61P7/02;A61P9/08;A61P9/10;A61P9/12;A61P9/14;A61P13/08;A61P13/12;A61P21/00;A61P21/04;A61P25/06;A61P35/00;A61P43/00;C07D207/16;C07D207/26;C07D207/27;C07D403/04;C07D405/00;C07D405/04;C07D405/14;C07D413/14;C07D417/14;C07D491/056;(IPC1-7):C07D405/04 |
主分类号 |
C07D491/048 |
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