1-[(4-Piperidinyl)methyl]-4-piperidine derivatives useful for treating gastrointestinal disorders

摘要

A 1[(4-piperidinyl)methyl]-4-piperidine derivative or a pharmaceutically acceptable acid addition salt thereof has the formula (I) wherein: Ar is a group of the formula (Ar-1) or (Ar-2); R1 is halogen; R2 and R4 are independently hydrogen or alkyl; R3 is hydrogen, alkyl or alkanoyl; R5 and R6 are independently hydrogen or alkyl; n is 1, 2 or 3; A is -Z-N(Q1)(Q2), -CO-R7 or -(CH2)p-CH(R8)-COR9; Z is -CO-, -CS- or -SO2-, Q1 and Q2 are independently hydrogen alkyl, cycloalkyl, optionally substituted phenyl or a phenylalkyl or Q1 and Q2 together with the nitrogen atom to which they attached form pyrrolidine, piperidine, hexahydroazepine, morpholine, thiomorpholine, or piperazine having optionally a lower alkyl or benzyl substituent on the other nitrogen atom); R7 is hydrogen, optionally substituted alkyl, alkoxy, alkoxycarbonyl, or an optionally substituted phenyl. p is 0, 1, 2, 3, 4 or 5; R8 is hydrogen or alkyl and R9 is alkyl or alkoxy. A pharmaceutical composition thereof is useful for treating diseases caused by the lack of stimulation on serotonin 4 receptors such as gastrointestinal disorders.