METHOD OF PREPARING LANSOPRAZOLE AND INTERMEDIATE THEREOF

摘要

PURPOSE: Provided is a method of preparing 2-(3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methylsulfinyl-1H-benzimidazol(hereinafter referred to lansoprazole) and its intermediate, 2-(3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methylthio-1H-benzimidazol. CONSTITUTION: Lansoprazole of the formula(I) is manufactured by; reacting 2-hydroxymethyl-3-methyl-4-(2,2,2-trifluroroethoxy)pyridine or its salt with a halogenating agent or an additive in a reaction solution to manufacture its intermediate, 2-(3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methylthio-1H-benzimidazol, of the formula(II) in high yield; and oxidizing it with hydrogen peroxide under the presence of a reaction solution and acid catalyst.