| 摘要 |
The derivatives of tetrahydropyridines (or 4-hydroxypiperidines)-butylazoles (I) are described. Where R1, R2 and R3 are either identical or different and represent a hydrogen atom, a C1-C4 alkyl group, a trifluoromethyl radical, a hydroxyl or alkoxyl radical, or, two adjacent radicals can form part of a ring; A represents a C atom and the dotted line represents an additional bond, or A represents a C atom bound to a hydroxyl group and the dotted line represents lack of an additional bond; Z1 is N or CR4; Z2 is N or CR5; Z4 is N or CR7; and R4, R5, R6 and R7, which can be equal or different, represent hydrogen, halogen, C1-C4 alkyl, aryl or substituted aryl, or two adjacent radicals can form part of another ring. Such derivatives are useful for the treatment of acute pain, neuropathic pain or nociceptive pain in mammals, including man.
|
