METHOD FOR STUDYING ANTI-AGGREGATION ACTION OF PREPARATIONS BY DETERMINING BLOOD PLATELET AGGREGATION IN VITRO

摘要

medicine. SUBSTANCE: method involves taking blood sample, stabilizing the sample, separating plasma reach in blood platelets by means of centrifuging, adding anti-aggregation agent, mixing and incubating plasma with and without the preparation at 36.5-37.5 C. Test system having anti-aggregation preparations of various mechanisms anti- aggregation activity with respect to blood platelets is applied. Preparation concentration in the test system is selected starting from the taken single dose. Blood platelets aggregation level index is to be determined before and after introducing the anti-aggregation preparation as adenosine diphosphate-induced blood platelets aggregation. Adenosine diphosphate-induced blood platelets aggregation of a preparation being by 50% and more different from the control sample, the preparation is considered to be efficient. EFFECT: enhanced effectiveness in individually selecting preparations.