发明名称 Silanol enzyme inhibitors
摘要 Compounds of formula (I, II, or III), wherein X is OH; Y is OH, H, lower alkyl of one to six carbons or heteroatoms or F; Z and Z' are independently H, lower alkyl or Q3Si where Q is lower alkyl or aryl; n is 3-50; n' is 2-50, A and B are independently a) alkyl of one to ten carbons or heteroatoms, b) aryl of four to ten carbons or heteroatoms, c) cyclic of three to ten carbons or heteroatoms, or moieties of the formulas (d, e, or f); R1-R11 groups are each independently hydrogen, alkyl of one to ten carbons or heteoatoms aryl of 4 to 14 carbons or heteroatoms, arylalkyl of five to twenty carbons or heteroatoms; unsubstituted carbonyl or substituted carbonyl. Heteroatoms are nitrogen, oxygen, silicon or sulfur. At least one of A or B, or both A and B are d), e), or f). The compounds of formula (I) inhibit protease enzymes and can be used as pharmaceuticals.
申请公布号 US6441212(B1) 申请公布日期 2002.08.27
申请号 US19980194715 申请日期 1998.12.17
申请人 RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK 发明人 SIEBURTH SCOTT MCN.;MUTAHI ALFRED M.;CHEN CHIEN-AN
分类号 C12N9/99;A61K31/695;A61P43/00;C07F7/08;C07F7/10;C07F7/21;C07K5/06;(IPC1-7):C07F7/02 主分类号 C12N9/99
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