| 摘要 |
A polymerizable 1,1-disubstituted ethylene formulation applicator includes polymerizable 1,1-disubstituted ethylene monomer. According to one embodiment, the monomer is surrounded by a container that may be engaged with an applicator tip The applicator tip has an internal cavity defined in an applicator tip body. A female fitting at an open end of the applicator tip body is in fluid communication with the cavity. A porous material member is connected to the applicator tip body to be in fluid communication with the internal cavity. The applicator tip may include a valve member disposed between the internal cavity and the porous material member. Also, the applicator tip may include a piercing or breaking member disposed substantially within the internal cavity. The container of monomer includes a male fitting that may be engaged with the female fitting of the applicator tip to form the applicator. The container also may include a polymerizable 1,1-disubstituted ethylene impervious barrier that may be pierced or broken by the piercing or breaking member when the male fitting is engaged with the female fitting. Depending on the particular application and the particular formulation, bioactive agents, viscosity modifiers, initiators, inhibitors and/or stabilizers may be added to the applicator, preferably in or on the porous material member. The container and one or more applicator tips form an applicator kit. Methods of applying a polymerizable 1,1-disubstituted ethylene formulation employ the various embodiments of the applicator tip, the applicator and the applicator kit, especially for the treatment of lacerated, burned, ulcerous, and laser-ablated tissues.
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