发明名称 |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
摘要 |
The present invention discloses a one-step process for the production of cytotoxic conjugates of maytansinoids and cell binding agents. Maytansinoids having a disulfide linker that bears a reactive moiety are linked to cell binding agents, such as antibodies, without prior modification of the cell binding agent. These conjugates are useful as therapeutic agents which are delivered specifically to target cells and are cytotoxic.
|
申请公布号 |
US6441163(B1) |
申请公布日期 |
2002.08.27 |
申请号 |
US20010867598 |
申请日期 |
2001.05.31 |
申请人 |
IMMUNOGEN, INC. |
发明人 |
CHARI RAVI V. J.;WIDDISON WAYNE C. |
分类号 |
A61K31/537;A61K47/48;A61P35/00;A61P35/02;C07D498/18;(IPC1-7):C07D491/12 |
主分类号 |
A61K31/537 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|