发明名称 |
POLYPEPTIDES AND POLYPEPTIDE ANALOGUES WITH INHIBITORY ACTIVITY AGAINST HUMAN ELASTASE |
摘要 |
Polypeptides, in particular the polypeptide of formula I: Ala-Gln-Glu-Pro-Val-Lys-Gly-Pro-Val-Ser-Thr-Lys-Pro-Gly-Ser-Cys-Pro- Ile-Ile-Leu-Ile-Arg-Cys-Ala-Met-Leu-Asn-Pro-Pro-Asn-Arg-Cys-Leu-Lys- Asp-Thr-Asp-Cys-Pro-Gly-Ile-Lys-Lys-Cys-Cys-Glu-Gly-Ser-Cys-Gly-Met- Ala-Cys-Phe-Val-Pro-Gln and analogues thereof which possess inhibitory activity against human leukocyte elastase. The polypeptides may be obtained by expression using plasmidic expression systems in hosts such as E. Coli and yeast, the polypeptide of formula I being also obtainable from psoriatic plaques.
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申请公布号 |
CA2018592(C) |
申请公布日期 |
2002.08.27 |
申请号 |
CA19902018592 |
申请日期 |
1990.06.08 |
申请人 |
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发明人 |
SCHRODER, JENS-MICHAEL;CHRISTOPHERS, ENNO;WIEDOW, OLIVER;EDGE, MICHAEL D.;PIOLI, DAVID |
分类号 |
A61K38/00;A61K38/55;A61P11/00;A61P17/00;A61P37/00;C07K1/20;C07K14/00;C07K14/39;C07K14/435;C07K14/47;C07K14/81;C07K16/00;C07K16/18;C07K16/38;C12N1/19;C12N1/21;C12N9/99;C12N15/09;C12N15/15;C12N15/81;C12P21/02;C12P21/08;C12R1/19;C12R1/865;(IPC1-7):C12N15/15;C07H21/00;C07K2/00;C12N1/00;A61K38/02;C12N5/10 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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