发明名称 |
2-ALKYLATED-CYCLODEXTRIN DERIVATIVES: REVERSAL AGENTS FOR DRUG-INDUCED NEUROMUSCULAR BLOCK |
摘要 |
Disclosed is a 2-alkylated-cyclodextrin derivative having the general formula I wherein m is 0-7 and n is 1-8 and m+n= 7 or 8; R is (CH2)p-phenylene-(CH2)q, (C1-6)alkylene, or (CH2)r-S-(C1-4)alkylene, of which each alkylene group may be substituted with 1-3 OH groups; p and r are independently 1-4; q is 0-4; X is COOH, SO2OH, (CH2-CH2-O)s-H or OH; s is 1-3; or a pharmaceutically acceptable salt thereof. The 2-alkylated-cyclodextrin derivatives are suitable for use in the reversal of drug-induced neuromuscular block. |
申请公布号 |
WO02064635(A1) |
申请公布日期 |
2002.08.22 |
申请号 |
WO2002EP01667 |
申请日期 |
2002.02.14 |
申请人 |
AKZO NOBEL N.V.;ZHANG, MINGQIANG;TARVER, GARY |
发明人 |
ZHANG, MINGQIANG;TARVER, GARY |
分类号 |
A61K45/00;A61K31/565;A61K31/715;A61K31/724;A61P25/02;A61P43/00;C08B37/16 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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