MODIFIED ANTIBODIES AND ANTIBODY FRAGMENTS WITH INCREASED DURATION OF ACTIVITY

摘要

Modified antibodies with improved pharmacokinetic properties are disclosed. The antibodies bind to one or more human integrin receptors selected from the group consisting of GPIIb/IIIa, alpha <v> beta 3 and Mac-1, and comprise one to about six organic moieties which are covalently bonded to specific sites on the antibodies. The organic moieties can each independently be a hydrophilic polymeric group, a fatty acid group, a fatty acid ester group, a lipid group or a phospholipid group. Also disclosed is a method of treating a human with a disease or disorder in which cells expressing GPIIb/IIIa, alpha v beta 3 and/or Mac-1 play a pathophysiological role. The method comprises administering an effective amount of one or more antibodies of the invention to a human in need thereof.