Method for identifying type 2 hypercarbic respiratory failure associated with community acquired pneumonia

摘要

A method of identifying patients having a predisposition to Type 2 Hypercarbic Respiratory Failure and/or an increased requirement for mechanical ventilation when they have community-acquired pneumonia (CAP) through detection of IL 10 gene polymorphisms at the -1082 site. The method can be used to diagnose predisposition or susceptibility to Type 2 Hypercarbic Respiratory Failure and/or an increased requirement for mechanical ventilation in patients with CAP. Compositions for said diagnosis are provided. Methods of treatment of CAP in such patient are provided, comprising identifying an individual having a predisposition or susceptibility to Type 2 Hypercarbic Respiratory Failure and/or an increased requirement for mechanical ventilation and subsequently treating that individual for such condition.