| 摘要 |
Polycyclic aniline derivs of formula (I) and their acid-addn. salts are new: (where X is O, S, CH or NR (R=H or lower alkyl); R1 is H, 116C alkylamino, 1-8C alkyl, (CH2)nPh, 2-6C alkynyl, (CH2)nOPh, (CH2)nNR6R7 or (CH2)nOH (n = 1, 2 or 3; R6 and R7 are 1-6C alkyl), and R2 is H, 1-6C alkyl, 1-6C aliphatic acyl, or NR1R2 is 4-12C azacycloalkyl, 4-(1-6c alkyl)-1-piperazinyl, morpholino, thiomorpholino or 1-piperazinyl; R3 is H, halogen, 3-Me, 5-Me, 2, 6-dimethy6, 3, 5-dimethyl, CHO, CH2OH, CH(Me)OH, 3-NR1R2, 1-NR1R2 or CH2SMe; R4 is a bridged polycyclic hydrocarbon residue bonded via a tert. C atom). Cpds. (I) are hypolipaemic (esp. hypocholesterolaemic) agents, esp. for oral administration. |
