发明名称 |
CRYSTALLIZATION OF IGF-1 |
摘要 |
Crystalline IGF-1 is provided along with a method for production thereof. Crystallizing IGF-1 comprises the steps of mixing an aqueous solution comprising IGF-1 with a reservoir solution comprising a precipitant to form a mixture; and crystallizing the mixture, optionally also recrystallizing and isolating the crystalline IGF-1. In addition, a method for identifying IGF-1 indirect agonists is provided using a detergent as a standard for the level of inhibition of binding of IGFBP-1 or IGFBP-3 to IGF-1 and/or using the coordinates of the binding pockets of IGF-1 to which a candidate indirect agonist binds for structure-based drug design.
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申请公布号 |
CA2431033(A1) |
申请公布日期 |
2002.08.22 |
申请号 |
CA20022431033 |
申请日期 |
2002.02.01 |
申请人 |
GENENTECH, INC. |
发明人 |
SCHAFFER, MICHELLE;ULTSCH, MARK;VAJDOS, FELIX |
分类号 |
G01N23/20;A61K38/00;A61P3/04;A61P3/10;A61P9/00;A61P13/12;A61P25/00;A61P31/18;A61P37/02;A61P43/00;C07K;C07K14/65;C30B;C30B29/58;(IPC1-7):C07K14/65 |
主分类号 |
G01N23/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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