COMBINED TRANSDUCTIONAL AND TRANSCRIPTIONAL TARGETING SYSTEM FOR IMPROVED GENE DELIVERY

摘要

The present invention provides a gene delivery system that combines transductional targeting via binding to angiotensin converting enzyme (ACE) expressed on pulmonary endothelial growth factor type 1 receptor (flt-1) promoter. Compared to either approach used alone, this combined targeting approach resulted in a dramatic improvement in the target: non target transgene expression ratio in vivo, thereby improving the prospects for pulmonary vascular gene therapy and establishing a fundamental principal for the use of targeting strategies generally.