发明名称 |
MODIFIED INTERFERON-ALPHA 2A AND 2B, AND CONJUGATE OF PEG DERIVATIVES THEREWITH |
摘要 |
PURPOSE: Provided are modified interferon-alpha 2a and 2b, and a conjugate of PEG derivatives therewith, to reduce physiological activity of interferon and increase sustaining time thereof in a living body. CONSTITUTION: The modified interferon-alpha 2a or 2b is prepared by substituting cysteine for 106 threonine or 161 leucine in wild type of human interferon-alpha 2a or 2b. PEG derivative specifically bonds to a cysteine residue to prepare the conjugate of PEG derivative with the above modified interferon alpha 2a or alpha 2b.
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申请公布号 |
KR20020067105(A) |
申请公布日期 |
2002.08.22 |
申请号 |
KR20010007476 |
申请日期 |
2001.02.15 |
申请人 |
SUNBIO INC. |
发明人 |
HYUN, CHANG MIN;LEE, HYEOK JONG;NOH, GWANG;PARK, MIN GU |
分类号 |
C07K14/56 |
主分类号 |
C07K14/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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