ADENOVIRAL TRANSDUCTION OF FRAGILE HISTIDINE TRIAD ( FHIT ) INTO CANCER CELLS

摘要

ne, and loss of Fhit protein expression is observed in many human cancers. The present invention provides a method for the treatment of cancers. Specifically, the invention provides a method for inducing apoptosis in cancer cells via introduction of a tumor suppressor gene into the cells. The present invention relates to the delivery of the FHIT gene by way of an adenoviral vector, or other DNA transport system, into the cancer cells of an individual. This invention has particular application to the treatment of esophageal cancer and other tumors that carry alterations of the FHIT gene.