PROCESS FOR PREPARATION OF HALOGENOALCOHOL DERIVATIVES

摘要

A process for preparation of halogenoalcohol derivatives represented by the general formula (1) and novel useful intermediates are provided. Halogenoalcohols of the general formula (1), i.e., (2S,3R)-N-Cbz-3-amino-1-halogeno-4-phenylsulfanylbutan-2-olderivatives, can be efficiently prepared from a publicly known starting compound, i.e., N-Cbz-S-phenyl-L-cysteine, through novel active ester derivatives and novel ylide compounds of the general formulae (4) and (5) and halomethyl ketone intermediates of the general formula (6).