发明名称 |
Gene delivery vectors with cell type specificity for primary human chondrocytes |
摘要 |
The present invention relates to a gene delivery vehicle comprising a recombinant adenovirus having a tropism for a primary human chondrocyte. By efficiently transducing a nucleic acid of interest into a primary chondrocytes, the gene delivery vehicle is able to at least in part improve the counteraction of cartilage disease. In one embodiment the recombinant adenovirus comprises a deletion in the gene encoding for fiber protein, which is replaced by a nucleic acid sequence encoding at least part of a fiber protein of a B-type adenovirus.
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申请公布号 |
US2002115218(A1) |
申请公布日期 |
2002.08.22 |
申请号 |
US20010928262 |
申请日期 |
2001.08.10 |
申请人 |
HAVENGA MENZO JANS E.;VOGELS RONALD;BOUT ABRAHAM |
发明人 |
HAVENGA MENZO JANS E.;VOGELS RONALD;BOUT ABRAHAM |
分类号 |
A61K48/00;A61P19/00;C12N5/10;C12N15/861;(IPC1-7):A61K48/00;C12N7/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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