N<8>,N<13>-DISUBSTITUTED QUINO[4,3,2-KL]ACRIDINIUM SALTS AS THERAPEUTIC AGENTS

摘要

The present invention pertains to certain N<8>,N<13>-disubstituted quino[4,3,2-kl]acridinium salts of formula (Q<->) which inhibit telomerase wherein: p is an integer from 0 to 4; q is an integer from 0 to 3; r is an integer from 0 to 4; each R is -H or a ring substituent; each R is -H or a ring substituent; each R is -H or a ring substituent; R is a nitrogen substituent; R is a nitrogen substituent; and, Q is an anion. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo , to inhibit telomerase, to regulate cell proliferation, and in the treatment of proliferative conditions, such as cancer.