TABLETS QUICKLY DISINTEGRATED IN ORAL CAVITY

摘要

Tablets which are quickly disintegrated in the oral cavity without giving any unpleasant taste in taking and quickly absorbed in the digestive tract thereby achieving the drug effect. These tablets contain a drug which is hardly soluble in water under neutral or alkaline conditions but highly soluble in water under acidic conditions with giving an unpleasant taste. These tablets can be produced by blending the drug with a water-soluble acidic substance, coating one or both of them with a water-soluble coating which is insoluble in alcoholic solvents, further adding a water-soluble binder which is soluble in alcoholic solvents and water-soluble saccharide(s), molding the mixture under low pressure and then treating with an alcoholic solvent.