Method for identifying compounds modulating the MAPK activity

摘要

In a method for identifying compounds for the treatment of disorders mediated by deregulation of the MAPK pathway related to structural and/or functional alterations of the endosomal/lysosomal system, compounds are tested for their ability to inhibit, on late endosomes/lysosomes, the interaction of p14 with MP1 or the interaction of the p14/MP1 complex with components of the MAPK pathway.