| 发明名称 |
Antisense inhibition of transforming growth factor-beta expression |
| 摘要 |
Compositions and methods are provided for modulating the expression of TGF-beta. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TGF-beta are preferred. Methods of using these compounds for modulation of TGF-beta expression and for treatment of diseases associated with expression of TGF-beta are also provided. Methods of sensitizing cells to apoptotic stimuli are also provided.
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| 申请公布号 |
US6436909(B1) |
申请公布日期 |
2002.08.20 |
| 申请号 |
US20000661753 |
申请日期 |
2000.09.14 |
| 申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
DEAN NICHOLAS M.;MURRAY SUSAN F. |
| 分类号 |
C12N15/09;A61K9/10;A61K31/7115;A61K31/712;A61K31/7125;A61K38/00;A61K48/00;A61P1/16;A61P9/00;A61P11/00;A61P13/12;A61P17/02;A61P27/02;A61P29/00;C07H21/04;C12N15/113;(IPC1-7):A61K48/00;C12Q1/68;C07H21/02;C12N15/85 |
主分类号 |
C12N15/09 |
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