GASTROPROTECTIVE PHARMACEUTICAL PREPARATIONS CONTAINING N-BENZYL-N-((1S,5S)-6,6-DIMETHYLBICYCLO[3,1,1]-HEPT-2-YLETHOXY-ETHYL)-MORPHOLINIUM SALTS

摘要

A method of inhibiting peripheral blood circulation disorders or damage such as hemorrhagic lesions induced by gastrotoxic doses of substances such as alcohol or non- steroid, antiinflammatory medicaments in the gastrointestinal tract of a mammal comprising administering to said mammal an effective peripheral circulation disorder or gastrointestinal damage inhibiting amount of a quaternary N-benzyl-N-{2-[2-((1S,5S)-6,6-dimethylbicyclo[3,1,1]hept-a- yl)-ethoxy]-ethyl}-morpholinium salt, and pharmaceutical compositions comprising a substance having a tendency to induce a peripheral blood circulation disorder or damage such as a hemorrhagic lesion in the stomach and/or intestinal wall of a mammal and an effective peripheral circulation disorder or gastrointestinal damage inhibiting amount of a quaternary N-benzyl-N-{2-[2-((1S,5S)-6,6- dimethylbicyclo[3,1,1]hept-2-yl)-ethoxy]-ethyl}-morpholinium salt.