发明名称 |
METHOD FOR PURIFICATION OF IBUPROFEN COMPRISING MIXTURES |
摘要 |
This invention pertains to a method of purifying ibuprofen-comprising reaction product mixtures. The method of purification is based on crystallization of ibuprofen from a hydrocarbon solvent and the discovery that there are impurity complexes in the ibuprofen-comprising reaction product mixtures which cannot be removed by crystallization from a hydrocarbon solvent. The method of the invention includes at least one step in which the impurity complex in a first ibuprofen- comprising mixture is destabilized or broken up, followed by crystallization of the ibuprofen from a second solution or mixture comprising the first ibuprofen-comprising mixture, whereby the impurities which were previously complexed can than be removed from the ibuprofen by the crystallization of ibuprofen from a solvent.
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申请公布号 |
CA2050709(C) |
申请公布日期 |
2002.08.20 |
申请号 |
CA19912050709 |
申请日期 |
1991.09.05 |
申请人 |
HOECHST CELANESE CORPORATION |
发明人 |
ZEY, EDWARD G.;SHOCKLEY, THOMAS H.;RYAN, DEBRA A.;MOSS, GARY L. |
分类号 |
C07C51/43;(IPC1-7):C07C51/43;C07C57/30 |
主分类号 |
C07C51/43 |
代理机构 |
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