发明名称 |
SUBSTITUTED AMYLOSE AS A MATRIX FOR SUSTAINED DRUG RELEASE |
摘要 |
A pharmaceutical sustained release tablet for oral administration is made of a compressed blend of at least two dry powders including a powder of a pharmaceutical drug and a powder of a sustained release matrix for the drug. The sustained release matrix is made of substituted amylose prepared by reacting, in a basic medium, amylose with an organic substituent having a reactive function that reacts with the hydroxy groups of the amylose molecule. This substituent is preferably an epoxy or halogen alkane or alcohol with such a matrix controlled and sustained release of a drug are achieved with a remarkable close-to-linear profile and a release time of from 9 to 20 hours.
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申请公布号 |
CA2271895(C) |
申请公布日期 |
2002.08.20 |
申请号 |
CA19972271895 |
申请日期 |
1997.10.22 |
申请人 |
UNIVERSITE DE MONTREAL |
发明人 |
CARTILIER, LOUIS;MOUSSA, ISKANDAR;CHEBLI, CHAFIC;BUCZKOWSKI, STEPHANE |
分类号 |
A61K47/36;A61K9/20;A61K9/22;A61K9/24;A61K9/28;(IPC1-7):A61K9/20;C08B33/04 |
主分类号 |
A61K47/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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