| 摘要 |
<p>This invention provides an animal having a persistent hypercoagulable state by implanting a cell, for example a tumor cell, in which the gene of human tissue factor is implanted to an experimental animal such as a mouse and then by growing said cell, thereby persistently supplying human tissue factor to said experimental animal. This animal model is useful for research and development of therapeutic agents for diseases having a persistent hypercoagulable state. The present invention also provides preventive or therapeutic agents for diseases having a persistent hypercoagulable state, a hypercoagulable state resulting from infections, venous thrombosis, arterial thrombosis, and diseases resulting from the hypertrophy of vascular media, said agent comprising an antibody against human tissue factor (human TF) as an active ingredient.</p> |
