| 发明名称 |
Bicyclic modulators of androgen and progesterone receptors, processes of their preparation as well as method for using thereof |
| 摘要 |
<p>The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.</p> |
| 申请公布号 |
CZ20020709(A3) |
申请公布日期 |
2002.08.14 |
| 申请号 |
CZ20020000709 |
申请日期 |
2000.08.25 |
| 申请人 |
LIGAND PHARMACEUTICALS INCORPORATED |
发明人 |
ZHI LIN;TEGLEY CHRISTOPHER;PIO BARBARA;ARJAN VAN OEVEREN CORNELIS;MOTAMEDI MEHRNOUCH;MARTINBOROUGH ESTHER;WEST SARAH;HIGUCHI ROBERT;HAMANN LAWRENCE;FARMER LUC |
| 分类号 |
A61K31/37;A61K31/4025;A61K31/404;A61K31/407;A61K31/416;A61K31/4178;A61K31/428;A61K31/47;A61K31/4704;A61K31/4709;A61K31/4725;A61K31/496;A61K31/517;A61K31/536;A61K31/5377;A61K31/538;A61K31/55;A61P5/26;A61P5/28;A61P5/34;A61P5/36;A61P7/04;A61P7/06;A61P13/08;A61P15/00;A61P15/04;A61P15/08;A61P15/10;A61P15/16;A61P15/18;A61P17/10;A61P17/14;A61P35/00;A61P43/00;C07D209/34;C07D209/96;C07D215/22;C07D215/227;C07D215/36;C07D215/38;C07D215/48;C07D239/80;C07D265/18;C07D265/36;C07D277/68;C07D311/14;C07D311/20;C07D401/04;C07D401/12;C07D405/04;C07D405/12;C07D409/04;C07D409/12;C07D413/04;C07D417/04;(IPC1-7):C07D215/00 |
主分类号 |
A61K31/37 |
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