发明名称 |
Microbial 9alpha-hydroxylation of steroids |
摘要 |
A method is described to construct genetically modified strains of steroid degrading micro-organisms wherein multiple genes involved in steroid nucleus degradation are inactivated, such as steroid dehydrogenase genes. Examples for such genes are kstD1 and kstD2: strains with multiple inactivated steroid degrading enzyme genes can be used in the accumulation of steroid intermediates with a high yield. A preferred accumulation product is 9 alpha -hydroxy-4-androstene-3,17-dione. |
申请公布号 |
CZ20021784(A3) |
申请公布日期 |
2002.08.14 |
申请号 |
CZ20020001784 |
申请日期 |
2000.10.17 |
申请人 |
AKZO NOBEL N. V. |
发明人 |
VAN DER GEIZE ROBERT;HESSELS GERDA;DIJKHUIZEN LUBBERT |
分类号 |
C12N1/21;C12N9/02;C12N15/01;C12N15/53;C12N15/63;C12N15/76;C12P33/00;C12P33/06 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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