发明名称 |
Poly-L-lactates as antitumour agents |
摘要 |
The anti-malignant tumor agent of the present invention comprises a mixture of poly L-lactates that are cyclic and linear oligomers having degrees of condensation of 3 to 23, which is prepared by dehydration condensation of L-lactic acid in a nitrogen atmosphere under stepwise reduced pressure and at an increasing temperature, drying ethanol- and methanol-soluble components in the resulting reaction solution under reduced pressure, subjecting the product to chromatography on a reverse phase ODS column, and after elution with 25 to 50 % aqueous acetonitrile at pH 2.0, eluting said mixture of poly L-lactates with 100 % acetonitrile at pH 2.0. <IMAGE> |
申请公布号 |
EP1103263(A3) |
申请公布日期 |
2002.08.14 |
申请号 |
EP20000310132 |
申请日期 |
2000.11.15 |
申请人 |
NAGASU, YOUICHIRO |
发明人 |
NAGASU, YOUICHIRO;AIZAWA, SHIN;NAGASU, MASAYA;IMANISHI, YOSHIO |
分类号 |
A61K31/74;A61K31/765;A61P35/00 |
主分类号 |
A61K31/74 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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