CARDIOMYOCYTES WITH ENHANCED PROLIFERATIVE POTENTIAL AND METHODS FOR PREPARING AND USING THE SAME

摘要

Described are methods in vitro and in vivo which involve the use of increased cyclin D2 activity to activate the cell cycle of cardiomyocytes as a baseline measure and/or in response to stimuli. Also described are vectors useful for these purposes, and cardiomyocyte cells exhibiting an activated cell cycle. Transgenic cyclin D2 animal models are also described.