发明名称 |
Carboxylic acids for synthesis of taxane derivatives |
摘要 |
Novel carboxylic acids of formula (VI), useful for preparing taxane derivatives of general formula (I) by esterifying protected baccatine (III) or protected diacetyl baccatin (III) with an acid of general formula (II). The products of general formula (I) are particularly useful for preparing taxol, Taxotere and analogs thereof having anti-tumor properties.
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申请公布号 |
US6433180(B1) |
申请公布日期 |
2002.08.13 |
申请号 |
US19970908807 |
申请日期 |
1997.08.08 |
申请人 |
AVENTIS PHARMA S.A. |
发明人 |
DENIS JEAN-NOEL;GREENE ANDREW-ELLIOT;KANAZAWA ALICE |
分类号 |
A61K31/395;A61K31/41;A61P35/00;A61P35/02;C07D263/04;C07D263/16;C07D305/14;C07D413/12;(IPC1-7):C07D263/06 |
主分类号 |
A61K31/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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