| 摘要 |
The instant invention provides compound of formula Iwherein:R1 is -H, -OH, -O(C1-C4 alkyl), -O-CO-(C1-C6 alkyl), -O-CO-O(C1-C6 alkyl), -O-CO-Ar in which Ar is optionally substituted phenyl, or -O-SO2-(C4-C6 alkyl);R2 is -H, -OH, -O(C1-C4 alkyl), -O-CO-(C1-C6 alkyl), -O-CO-O(C1-C6 alkyl), -O-CO-Ar in which Ar is optionally substituted phenyl, -O-SO2-(C4-C6 alkyl), -F, -Cl, or -Br;n is an integer from 5 to 8;R3 and R4 each are independently C1-C4 alkyl, or combine to form, with the nitrogen to which they are attached, piperidinyl, pyrrolidinyl, methylpyrrolidinyl, dimethylpyrrolidinyl, or hexamethyleneimino;or a pharmaceutically acceptable salt or solvate thereof, intermediates, pharmaceutical formulations, processes, and methods of use.
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